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Alkaline Phosphatase Fluid 5+1 DGKC

Alkaline Phosphatase Fluid 5+1 DGKC

Intended use
In vitro test for the quantitative determination of alkaline phosphatase (ALP) in human serum und plasma on automated clinical chemistry analysers.

Summary
Alkaline phosphatase in serum consists of four structural genotypes: the liver-bone-kidney type, the intestinal type, the placental type and the variant from germ cells. It occurs in osteoblasts, hepatocytes, the kidneys, spleen, placenta, prostate, leukocytes and the small intestine. The liver-bone-kidney type is particularly important.
A rise in the alkaline phosphatase activity occurs with all forms of cholestasis, particularly with obstructive jaundice. It is also elevated in diseases of the skeletal system, such as Paget’s disease, hyperparathyroidism, rickets and osteomalacia, as well as with fractures and malignant tumors. A considerable rise in the alkaline phosphatase
activity is sometimes seen in children and juveniles. It is caused by increased osteoblast activity following accelerated bone growth. Various references values for the purposes of clinical evaluation have been assigned to differing age groups.

Test principle
Colorimetric assay in accordance with a standardized method

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